sciadv202410issue-48largecover
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Glycoprotein brush protects our lung from inhaled infectious particulates

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Voxelated Bioprinting

Voxel-bioprinted “raspberry” like hollow sphere

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Vascularized Network

Human umbilical vein endothelial cells form vascularized network in 3D

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Bottlebrush Polymer Networks

Soft as “watery” biological tissues but dry as metal

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Tough, self-healing polymers

Tough as metal but can self-heal upon break

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Foldable Bottlebrush Polymers

A paradigm-shifting building block for soft (bio)materials innovation

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Voxelated Bioprinting

Use bio-ink droplets as building blocks to create 3D tissues

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Renormalized Rouse Model

Discovery that challenges a 30-year-old dogma in associative polymers

Our lab’s research lies at the interface of soft (bio)materials and biology. We seek to understand and control the interactions between soft (bio)materials and living systems to address critical challenges in sustainability and health.

We achieve this through a combination of experimental and theoretical approaches. Our core expertise includes polymers and soft matter, biomaterials, voxel bioprinting, and additive manufacturing of soft and inorganic matter. Complementary expertise include molecular engineering, bioengineering, macro-/micro-rheology, in situ characterization, microscopy and image analysis, microfluidics, and in vivo animal studies.

Our research is highly interdisciplinary and collaborative. We work closely with experts from different fields to identify and solve problems of both fundamental importance and practical value. Members of our group often start with one area of research and gradually broaden their horizon spanning from physics, chemistry, biology, engineering to medicine. 

Current research is divided into four areas: (1) polymers and soft matter; (2) advanced (bio)manufacturing; (3) biomaterials; (4) bioengineering. Along with these research thrusts, in parallel to efforts toward practical applications, we seek to answer three fundamental scientific questions:

  1. What are the molecular mechanisms for nonlinear (mechanical, electric, magnetic, and optical) properties of soft materials under large deformations?
  2. How do soft (bio)materials interact with biological objects?
  3. Can we use soft matter principles to understand the rules of life?